| | ID | | Name | Team | | Points | | Return to Top 10 |
| | 165 | | Sedin, Daniel | VAN | | 52 |
| | 164 | | Sedin, Henrik | VAN | | 53 |
| | 9 | | Seguin, Tyler | BOS | | 43 |
| | 223 | | Seidenberg, Dennis | BOS | | 19 |
| | 220 | | Sekera, Andrej | BUF | | 8 |
| | 1 | | Selanne, Teemu | ANA | | 46 |
| | 172 | | Semin, Alexander | WAS | | 28 |
| | 80 | | Setoguchi, Devin | MIN | | 18 |
| | 36 | | Sharp, Patrick | CHI | | 40 |
| | 245 | | Shattenkirk, Kevin | STL | | 23 |
| | 26 | | Skinner, Jeff | CAR | | 28 |
| | 229 | | Smith, Craig | NSH | | 30 |
| | 63 | | Smyth, Ryan | EDM | | 34 |
| | 117 | | Spezza, Jason | OTT | | 50 |
| | 154 | | St. Louis, Martin | TB | | 45 |
| | 25 | | Staal, Eric | CAR | | 37 |
| | 138 | | Staal, Jordan | PIT | | 21 |
| | 215 | | Stafford, Drew | BUF | | 23 |
| | 155 | | Stamkos, Steven | TB | | 54 |
| | 40 | | Stastny, Paul | COL | | 31 |
| | 147 | | Steen, Alexander | STL | | 24 |
| | 22 | | Stempniak, Lee | CGY | | 24 |
| | 145 | | Stewart, Chris | STL | | 20 |
| | 73 | | Stoll, Jarret | LA | | 14 |
| | 106 | | Streit, Mark | NYI | | 28 |
| | 207 | | Subban, P.K. | MON | | 19 |
| | 137 | | Sullivan, Steve | PIT | | 25 |
| | 20 | | Tanguay, Alex | CGY | | 23 |
| | 108 | | Tavares, John | NYI | | 53 |
| | 99 | | Tedenby, Mattias | NJ | | 6 |
| | 244 | | Thomas, Tim | BOS | | 0 |
| | 139 | | Thornton, Joe | SJ | | 41 |